Thu. Jul 18th, 2024
A plate of Japanese horseradish or wasabi on a wooden table

In a world filled with endless options for enhancing cognitive function, a new study brings us a delightful surprise.

The study reveals that the traditional Japanese spice, wasabi, might hold the key to improving cognitive performance in individuals aged 60 and above.

Yes, you read that right! This pungent condiment offers not only a burst of flavor but also a potential boost for our aging brains.

In this article, we’ll dive into the details of this intriguing study and explore the benefits of wasabi’s secret ingredient, 6 methylsulfinyl hexyl isothiocyanate (6-MSITC).

The Power of 6-MSITC

At the heart of this fascinating discovery is the bioactive compound, 6-MSITC, found in wasabi.

This compound has long been associated with its antioxidant and anti-inflammatory properties, both of which play a crucial role in protecting our cells from damage.

While previous studies have hinted at the positive impact of 6-MSITC on cognition, this latest research seeks to shed light on its potential benefits for older adults, who are most vulnerable to cognitive decline and related conditions, such as dementia.

“Previous studies suggested that antioxidants and anti-inflammatories have an important role in cognitive health in older adults,” write the researchers in their published paper. “Therefore, 6-MSITC is expected to have a positive effect on cognitive performances in older adults.”

Unlocking the Cognitive Potential

The research team conducted a 12-week trial involving 72 adults aged over 60. Participants were randomly divided into two groups, with one group taking a daily dose of a wasabi tablet, while the other received a placebo tablet. The results were nothing short of intriguing.

Memory Matters

After the experiment concluded, those who had consumed wasabi tablets displayed a significant improvement in their episodic memory (the ability to recall events from the past) and working memory (the capacity to hold information temporarily).

These findings indicate that the wasabi and its key component, 6-MSITC, may have a particularly positive influence on the hippocampus, a crucial region of the brain responsible for memory functions.

“The 12 weeks’ intake of 6-MSITC appears to selectively enhance working and episodic memory functions in healthy older adults,” note the researchers. This opens up exciting possibilities for supporting cognitive health as we age.

While the results are promising, the study acknowledges its limitations. Notably, no measurements of antioxidant or anti-inflammatory biomarkers were taken, leaving room for speculation regarding the precise mechanisms through which wasabi and 6-MSITC enhance memory function. However, the link between 6-MSITC-containing wasabi and improved memory function is undeniably clear.

The researchers are now eager to delve deeper into the biological and molecular aspects of this phenomenon.

Further investigations are needed to understand the intricate workings behind the cognitive benefits of wasabi.

Nevertheless, this study reminds us that simple dietary choices can have a significant impact on our cognitive well-being as we age.

A Recipe for a Brighter Future

“Older adults with lower cognitive performance often face challenges in their daily activities, such as shopping, banking, and cooking,” highlight the researchers. Therefore, enhancing cognitive functions in older adults is of paramount importance, not only for their quality of life but also for maintaining their independence.

The humble wasabi, with its extraordinary 6-MSITC content, may be the unexpected hero in the quest for preserving cognitive function in our golden years. While more research is needed to uncover the full scope of its benefits, incorporating this pungent delight into your diet could be a simple, enjoyable way to nourish your aging brain.


  1. Can I obtain the cognitive benefits of wasabi by consuming it in its traditional form?
    While this study focused on wasabi tablets, traditional consumption of wasabi in sushi and other dishes may also offer benefits. However, the concentration of 6-MSITC in these foods may vary.
  2. Are there any side effects of consuming wasabi or 6-MSITC?
    Wasabi is generally safe when consumed in moderate amounts. However, excessive consumption may lead to a burning sensation in the mouth. It’s always wise to enjoy it in moderation.
  3. How can I incorporate more wasabi into my diet?
    You can add wasabi to your meals, such as sushi, sashimi, and even salad dressings. Experiment with different dishes to find your preferred way to enjoy this unique spice.
  4. Is wasabi a suitable option for individuals with allergies?
    Some individuals may be allergic to wasabi. If you have a known allergy to horseradish, mustard, or similar foods, it’s advisable to exercise caution or consult a healthcare professional.
  5. Where can I access more information about cognitive health and dietary choices?
    For a deeper understanding of cognitive health and dietary strategies, consult with a healthcare professional or nutritionist who can provide personalized guidance.

Published 30 October 2023 in Nutrients ;
Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial


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